منابع مشابه
Statin induced proteinuria: renal injury or renoprotection?
Meticulous blood pressure control, particularly with antiproteinuric medications, such as ACE inhibitors and angiotensin receptor blockers (ARBs), have proven to be effective in slowing the progression of kidney disease and are pillars in the modern management of chronic kidney disease (CKD). However, despite careful attention to blood pressure lowering and the use of ACEi and/or ARBs, progress...
متن کاملDiabetic nephropathy: evidence for renoprotection and practice.
Patients with diabetic renal disease have a very bad prognosis. Hyperfiltration, related to poor metabolic control, occurs early on in the disease process. There is also an increase in albumin excretion which can be readily reversed by eVective glycaemic control at clinical diagnosis (fig 1). A phase is then entered during which most patients are normoalbuminuric. However, after approximately 1...
متن کاملDPP-4 inhibitors-renoprotection in diabetic nephropathy?
There is no doubt that rates of chronic kidney disease are escalating and that this rise is the main contributor to the increasing prevalence of diabetic nephropathy. It is also clear that the increase in kidney failure continues despite tight blood glucose and blood pressure control, as well as renin-angiotensin system blockade. In response, research into novel therapies to treat diabetic neph...
متن کاملOptimal dose of losartan for renoprotection in diabetic nephropathy.
BACKGROUND Angiotensin II subtype-1 receptor antagonists represent a valuable new class of drugs in the treatment of diabetic nephropathy. The aim of our study was to evaluate the optimal dose of losartan for renoprotection and blood pressure reduction in diabetic nephropathy. METHODS Fifty consecutive hypertensive type 1 diabetic patients with diabetic nephropathy received increasing doses o...
متن کاملRenoprotection and renin-angiotensin system blockade in diabetes mellitus.
Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) in the United States, and accounts for 35% of all the patients with ESRD entering a dialysis program; 63% of patients with diabetic nephropathy have type II diabetes mellitus. Hypertension is a major risk factor for renal disease and is common in people with diabetes mellitus. Strategies for preventing the progressi...
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ژورنال
عنوان ژورنال: Nature Reviews Nephrology
سال: 2020
ISSN: 1759-5061,1759-507X
DOI: 10.1038/s41581-020-0308-3